Hepatitis C Drugs May Help Fight COVID-19, Suggests Study

Hepatitis C Drugs May Help Fight COVID-19, Suggests Study

Both SARS-CoV-2 and the hepatitis C virus are a virus of the same type. (Representational)

Berlin:

Several drugs approved for the treatment of hepatitis C viral infection have been identified as potential candidates against COVID-19 caused by the SARS-CoV-2 coronavirus, according to a study based on extensive calculations using supercomputer simulations.

Researchers from Johannes Gutenberg University Mainz (JGU) in Germany simulated the way that about 42,000 different substances listed in open databases bind to certain proteins of SARS-CoV-2, and thereby inhibit the penetration of the virus into the human body or its multiplication.

Using the powerful MOGON II supercomputer operated by JGU and the Helmholtz Institute Mainz, the researchers made more than 30 billion single calculations within two months.

They found that compounds from the four hepatitis C drugs simeprevir, paritaprevir, grazoprevir, and velpatasvir have a high affinity to bind SARS-CoV-2 very strongly and may therefore be able to prevent infection.

“This computer simulation method is known as molecular docking and it has been recognised and used for years. It is much faster and less expensive than lab experiments,” said Professor Thomas Efferth from JGU, lead author of the study published in the Bulletin of the World Health Organization.

“As far as we know, we were the first to have used molecular docking with SARS-CoV-2. And it is fantastic news that we have found a number of approved hepatitis C drugs as promising candidates for treatment,” Mr Efferth said.

The results are also supported by the fact that both SARS-CoV-2 and the hepatitis C virus are a virus of the same type, a so-called single-stranded RNA virus, explained Efferth.

According to the researchers, a natural substance from the Japanese honeysuckle (Lonicera japonica), which has been used in Asia against various other diseases for some time now, might be another strong candidate against SARS-CoV-2.

“Our research results now need to be checked in laboratory experiments and clinical studies,” said Mr Efferth.

Molecular docking had already been used successfully in the search for active substances against the coronaviruses MERS-CoV and SARS-CoV, he added.

World

35,82,465Cases

21,68,535Active

11,62,418Recovered

2,51,512Deaths

Coronavirus has spread to 187 countries. The total confirmed cases worldwide are 35,82,465 and 2,51,512 have died; 21,68,535 are active cases and 11,62,418 have recovered as on May 5, 2020 at 9:18 am.

India

46,433 3900Cases

32,138 2685Active

12,727 1020Recovered

1,568 195Deaths

In India, there are 46,433 confirmed cases including 1,568 deaths. The number of active cases is 32,138 and 12,727 have recovered as on May 5, 2020 at 8:00 am.

State & District Details

State Cases Active Recovered Deaths

DistrictCases

Mumbai3029

Pune660

Thane465

Nashik96

Nagpur76

Mumbai Sub Ur67

Yavatmal32

Aurangabad30

Sangli27

Ahmednagar27

Sholapur21

Buldhana21

Palaghar17

Akola17

Raigad17

Satara14

Kolhapur8

Latur8

Ratnagiri7

Amravati6

Jalgaon3

Osmanabad3

Sindhudurg (kudal)2

Chandrapur2

Dhule2

Beed1

Washim1

Parbhani1

Jalna1

Nandurbar1

Gondia1

Hingoli1

Details Awaited*9877

14541 1567

11493 1182

2465 350

583 35

DistrictCases

Ahmedabad1298

Surat338

Vadodara188

Rajkot40

Bhavnagar32

Anand28

Bharuch23

Gandhi Nagar17

Patan15

Narmada12

Panchmahal11

Banaskantha10

Arvalli8

Chhota Udepur7

Kutch6

Mehsana6

Botad5

Porbandar3

Mahisagar3

Kheda3

Gir Somnath3

Dahod3

Sabarkantha2

Valsad2

Morbi1

Jamnagar1

Tapi1

Details Awaited*3738

5804 376

4290 194

1195 153

319 29

DistrictCases

Tj From Quaritine1080

Central Delhi184

South East130

West Delhi122

South Delhi70

North Delhi60

Shahadara48

South West Delhi42

East Delhi38

New Delhi37

North West Delhi32

North East Delhi25

Details Awaited*3030

4898 349

3403 280

1431 69

64

DistrictCases

Chennai303

Coimbatore133

Tiruppur109

Dindigul76

Erode70

Tirunelveli62

Chengalpattu53

Tiruchirapalli50

Namakkal50

Thiruvallur48

Thanjavur46

Madurai46

Nagapattinam44

Theni43

Karur42

Ranipet39

Villupuram36

Thoothukudi27

Thiruvarur27

Cuddalore26

Tenkasi26

Salem24

Vellore22

Virudhunagar19

Tirupattur17

Nagerkoil (kanyakumari)16

Sivagangai12

Tiruvannamalai12

Ramanathapuram11

Udagamandalam9

Kancheepuram9

Perambalur5

Ariyalur4

Kalllakurichi3

Pudukottai1

Details Awaited*2030

3550 527

2110 496

1409 30

31 1

DistrictCases

Jaipur537

Jodhpur228

Bharatpur102

Kota99

Tonk95

Banswara60

Iran Evacuees60

Nagaur58

Jhunjhunu37

Bikaner35

Jaisalmer32

Bhilwara28

Ajmer23

Jhalawar20

Churu14

Dausa13

Alwar7

Dungarpur5

Sawai Madhopur5

Udaipur4

Hanumangarh3

Karauli3

Pali2

Pratapgarh2

Sikar2

Dholpur1

Barmer1

Details Awaited*1585

3061 175

1590 131

1394 38

77 6

DistrictCases

Indore915

Bhopal277

Khargon41

Dhaar41

Khandwa (east Nimar)32

Ujjain29

Raisen29

Hoshangabad25

Jabalpur25

Barwani24

Dewas18

Vidisha13

Ratlam13

Morena13

Mandsaur9

Agar8

Shajapur6

Sheopur-kalan4

Alirajpur3

Gwalior3

Sagar2

Shivpuri2

Chindwara2

Betul2

Rajgarh1

Dindori1

Tikamgarh1

Details Awaited*1403

2942 96

1979 87

798

165 9

DistrictCases

Agra241

Lucknow167

Gautam Budha Nagar98

Meerut75

Saharanpur72

Kanpur59

Firozabad58

Moradabad58

Ghaziabad41

Shamli26

Bijnor26

Basti19

Bulandshahar18

Sitapur17

Hapur17

Amroha17

Baghpat15

Rampur15

Varanasi14

Budaun13

Azamgarh7

Auraiya7

Sambhal7

Mathura6

Maharajganj6

Ghazipur6

Kannauj6

Pratapgarh6

Bareilly6

Muzaffar Nagar5

Jaunpur5

Lakhimpur Kheri4

Mainpuri4

Hathras4

Kanshi Ram Nagar (kasganj)3

Mirzapur3

Etah3

Etawah3

Kaushambi2

Banda2

Pilibhit2

Hardoi2

Rae-bareilly2

Unnao1

Sultanpur1

Bara-banki1

Sant Kabir Nagar1

Shahjahanpur1

Sant Ravi Das Nagar (bhadoi)1

Mau1

Gonda1

Allahabad1

Details Awaited*1590

2766 121

1914 66

802 48

50 7

DistrictCases

Kurnool158

Guntur128

Krishna76

Nellore67

Prakasam44

Kadapa37

West Godavari35

Anantapur29

Chittoor28

East Godavari24

Visakhapatnam20

Details Awaited*1004

1650 67

1090 28

524 36

36 3

DistrictCases

Kolkata184

Howrah79

North 24 Parganas46

Purba Mednipur21

Hooghly12

South 24 Parganas9

Kalimpomg7

Paschim Burdwan7

Nadia6

Jalpaiguri5

Darjeeling4

Paschim Mednipur4

Diamond Harbour-hd3

Murshidabad2

Basirhat-hd1

Purba Burdwan1

Nandigram-hd1

Details Awaited*867

1259 296

908 131

218 67

133 98

DistrictCases

Sasnagar61

Jalandhar48

Patiala26

Pathankot24

Nawanshahr (sbs Nagar)19

Ludhiana16

Amritsar11

Mansa11

Hoshiarpur7

Moga4

Rupnagar3

Sangrur3

Faridkot3

Kapurthala2

Barnala2

Fatehgarh Sahib (sarhind)2

Muktsar1

Gurdaspur1

Firozepur1

Details Awaited*988

1233 131

1089 125

121 4

23 2

DistrictCases

Hyderabad472

Suryapet75

Nizamabad56

Vikarabad36

Hyderabad Rural (ranga Reddy)35

Gadwal (jogulamba)32

Medchal30

Warangal25

Adilabad19

Karimnagar19

Nirmal18

Yadadri15

Nalgonda15

Mahaboobnagar12

Kamareddy11

Sangareddy8

Khammam7

Medak6

Asifabad (komarambhim)5

Kothagudem (badadri)4

Jagityal3

Siricilla (rajanna)3

Bhupalpally (jayashanker)3

Nagarkurnool2

Peddapally2

Mulugu2

Janagoan2

Siddipet1

Mahabubabad1

Details Awaited*166

1085 3

471

585 95

29

DistrictCases

Bandipora81

Srinagar79

Baramulla43

Kupwara31

Jammu27

Shopian22

Udhampur20

Ganderbal14

Badgam13

Kulgam6

Rajouri4

Samba4

Anantnag3

Pulwama3

Details Awaited*376

726 25

415 9

303 16

8

DistrictCases

Mysuru84

Bbmp66

Belagavi42

Vijayapura32

Kalburgi27

Bengaluru (u)23

Bagalkote21

Chikkaballapur16

Bidar15

Dakshin Kannada14

Ballari13

Mandya12

Bengaluru (r)12

Uttara Kannada11

Dharwad7

Gadag4

Udupi3

Tumakuru2

Davanagere2

Kodagu1

Chitradurga1

Details Awaited*243

651 37

303 7

321 28

27 2

DistrictCases

Siwan29

Nalanda28

Munger20

Begusarai9

Patna7

Gaya5

Buxar4

Gopalganj3

Nawada3

Bhagalpur1

Bhojpur1

Lakhisarai1

Saran1

Vaishali1

Details Awaited*415

528 25

394 20

130 5

4

DistrictCases

Nuh57

Faridabad42

Gurgaon38

Palwal34

Panchkula18

Ambala12

Sonepat7

Karnal6

Panipat5

Sirsa4

Yamunanagar3

Bhiwani3

Kurukshetra2

Kaithal2

Jind2

Hissar2

Rohtak1

Fatehabad1

Charkhi Dadri1

Details Awaited*277

517 75

257 65

254 9

6 1

DistrictCases

Kasaragode170

Cannanore(kannur)92

Ernakulam24

Kozhicode (calicut)20

Malappuram20

Pathanamthitta17

Thiruvananthapuram14

Thrissur13

Idukki10

Kollam9

Palakkad8

Alappuzha5

Kottayam3

Wyanad3

Details Awaited*92

500

34

462 61

4

DistrictCases

Khurda (bhuvaneshwar)46

Bhadrak8

Balasore3

Jajpur2

Kalahandi2

Kendrapara2

Sundargarh2

Cuttack1

Dhenkanal1

Puri1

Details Awaited*101

169 7

108 3

60 4

1

DistrictCases

Ranchi25

Bokaro10

Hazaribagh3

Dhanbad2

Simdega2

Deoghar1

Giridh1

Koderma1

Details Awaited*70

115

85

27 5

3

DistrictCases

Chandigarh26

Details Awaited*76

102 8

80 5

21 2

1 1

DistrictCases

Dehradun24

Nainital9

Haridwar7

Udhamsingh Nagar4

Almora1

Pauri Garhwal1

Details Awaited*14

60

20

39

1 1

DistrictCases

Korba28

Raipur5

Bilaspur1

Durg1

Rajnandgaon1

Details Awaited*22

58 1

22 1

36

0

DistrictCases

Golaghat9

Marigaon6

Dhubri4

Goalpara4

Nalbari4

Kamrup Metro2

Cachar1

Hailakandi1

Kamrup1

Karimganj1

Lakhimpur1

S Mancachar1

Details Awaited*8

43

10

32

1

DistrictCases

Leh (ladakh)14

Details Awaited*27

41

24

17

0

DistrictCases

Una16

Solan9

Chamba6

Kangra5

Hamirpur2

Sirmaur1

Details Awaited*2

41 1

6 1

34

1

DistrictCases

South Andaman16

Details Awaited*17

33

1

32

0

DistrictCases

Gomati1

North Tripura1

Details Awaited*27

29 13

27 13

2

0

DistrictCases

East Khasi Hills11

Details Awaited*1

12

11

0

1

DistrictCases

Puducherry6

Details Awaited*2

8

3

5

0

DistrictCases

North Goa6

South Goa1

7

0

7

0

DistrictCases

Imphal West1

Thoubal1

2

0

2

0

DistrictCases

Aizwal West1

1

1

0

0

1

0

1

0

Source: https://www.ndtv.com/world-news/coronavirus-hepatitis-c-drugs-may-help-fight-covid-19-suggests-study-2223636